Infertility Assessment - Versys Clinics

Infertility Assessment

The first step in infertility treatment is the assessment, aimed at identifying possible causes and gaining a comprehensive understanding of the background of infertility. We consider it especially important that both the female and male partners undergo careful and thorough evaluation. The assessment follows the accredited protocol of Versys Clinics ESHRE ARTCC (C-0004), which adheres to the highest international professional guidelines. Based on the test results, our specialists create a personalized treatment plan for the couple. All required examinations are available at Versys Clinics Human Reproduction Institute and can be completed within a few personal visits without a waiting list.

ESHRE ARTCC Accredited Protocol (C-0004)

FEMALE EVALUATION

1. Blood tests, first round (not cycle-dependent):

Viral screening
- HIV 1-2 antibodies and HIV-1 antigen
- Hepatitis B virus (HBV):
  - HBsAg (surface antigen)
  - Anti-HBs (antibody indicating immunity)
  - Anti-HBc (marker of previous infection)
- Hepatitis C virus (HCV) – anti-HCV
- Cytomegalovirus (CMV) – IgG, IgM
- Rubella – IgG, IgM
- Herpes simplex virus (HSV) 1-2 – IgG, IgM
- Treponema pallidum (IgG/IgM and PRP)
- Toxoplasma antibodies
Karyotyping (genetic chromosomal testing)
Anti-Müllerian Hormone (AMH)
Fasting insulin resistance test (0'-60'-120' insulin + glucose)
Complete blood count, ESR, electrolytes, liver/kidney profile, lipids, coagulation panel
Blood type + Antibody screen
Thrombophilia screening: Factor V, Factor II, MTHFR
Immunological antibody screening (ANA, ENA, ds-DNA, Cardiolipin G/A/M, B2-GPI IgG/IgA/IgM, Annexin V IgG, Annexin V IgM, Anti-prothrombin antibodies, Anti-TPO, Anti-TG, TTG IgA, TTG IgG)
Vitamin D level determination

2. Blood tests, second round:

Basal hormones (cycle day 2–5): FSH, LH, TSH, PRL, E2, P4, Testosterone, DHEA-S

3. Other reproductive tests:

Endometrial receptivity analysis (ERMap / ERA): Assessment of the endometrium's readiness for implantation, allowing for the determination of the most optimal timing for embryo transfer.

Endometrial microbiome analysis (MicroBioMap – EMMA + ALICE): Examination of the bacterial composition of the endometrium to identify potential implantation issues caused by chronic endometritis or an imbalanced microbiome.

Endometrial immunological assessment (Im Map): Evaluation of the immunological status of the endometrium.

Carrier screening – genetic carrier screening: Screening for genetic mutations that may be carried by the individual.

WOMAM test: Genetic assessment of the risk for miscarriage and other pregnancy complications related to thrombosis.

KIR / HLA-C genotyping: Screening for the risk of maternal immune rejection of the embryo.

Gynecological examinations:

Transvaginal ultrasound
Cytology
Vaginal swab culture
STD 7 panel:
- Gardnerella
- Trichomonas
- Gonorrhea
- Chlamydia
- Mycoplasma
- Ureaplasma
- Herpes
Diagnostic hysteroscopy
Surgical hysteroscopy if needed

MALE EVALUATION

Blood tests:

Viral screening
- HIV 1-2 antibodies and HIV-1 antigen
- Hepatitis B virus (HBV):
  - HBsAg
  - Anti-HBs
  - Anti-HBc
- Hepatitis C virus (HCV) – anti-HCV
- Treponema pallidum (IgG/IgM and PRP)
Karyotyping
Thrombophilia screening: Factor V, Factor II, MTHFR
Hormone profile: FSH, LH, TSH, Prolactin, Estradiol, Testosterone, Free Testosterone
Vitamin D level

Andrological tests:

Semen analysis (spermiogram)
Semen culture
STD 6 panel:
- Gardnerella
- Trichomonas
- Gonorrhea
- Chlamydia
- Mycoplasma
- Ureaplasma
Sperm DNA fragmentation (flow cytometry)
Acrosome reaction test
ROS (flow cytometry)

Comprehensive Assessment for Both Partners

Our thorough evaluation protocol ensures that all potential causes of infertility are identified, allowing our specialists to create the most effective personalized treatment plan for your unique situation.