Treatment Process - Versys Clinics

Treatment Process

After the assessment and evaluation of the test results, we begin the couple's personalized treatment. If necessary, any required surgical or other procedures are performed first. These are generally followed by a quick recovery, after which the targeted fertility-supporting therapy can begin.

1 Timed Intercourse with Cycle Monitoring

Timed intercourse is a simple and natural method to support conception, during which the woman's menstrual cycle is continuously monitored to determine the exact time of ovulation. The goal is to ensure that intercourse occurs at the most favorable time when the chance of fertilization is highest.

Cycle monitoring process:

The cycle is counted from the first day of menstruation (this is day 1 of the cycle).
Between days 8–12 of the cycle, the ovaries and endometrium (endometrial lining) are examined via transvaginal ultrasound:
- The growth and size of the dominant follicle are monitored.
- The thickening of the endometrium is tracked, which is essential for implantation.
If follicular growth is appropriate, follow-up ultrasounds are performed until ovulation is imminent.
Ovulation timing:
- May occur naturally and is monitored by ultrasound and hormone levels.
- Or it may be triggered by an ovulation-inducing injection (e.g., Ovitrelle), which predicts follicle rupture within approximately 36 hours.

Timing of intercourse:

The doctor gives precise guidance on the most suitable day and time for intercourse, typically the evening before ovulation and the day of ovulation are the most ideal.
Proper timing significantly increases the chances of natural conception.
In some cases, hormonal support (e.g., progesterone supplementation) is added to help implantation succeed.

2 Insemination (IUI)

Insemination is a simple, quick, and painless procedure in which the partner's washed, concentrated sperm is placed directly into the uterine cavity around the time of ovulation. This brings the sperm closer to the egg, increasing the chance of fertilization.

Success rate averages 10–20%, depending on age, hormone levels, and sperm quality.

2.1 IUI in natural cycle:

In this case, the procedure is performed in line with the woman's natural cycle.

Cycle monitoring:

The cycle starts from the first day of menstruation.
Between cycle days 8–12, the ovaries and uterine lining are examined via transvaginal ultrasound:
- The growth of the dominant follicle is monitored.
- The thickness of the endometrium is assessed, which is crucial for implantation.
Continuous ultrasound monitoring is conducted until the follicle reaches the appropriate size.

Timing of ovulation:

May occur naturally, tracked by hormone tests and ultrasound.
Or an ovulation-inducing injection (e.g., Ovitrelle) may be used to time follicle rupture precisely.

Insemination procedure:

The procedure takes place approximately 36 hours after ovulation, timed precisely by the doctor.
The procedure lasts about 5–10 minutes, is completely painless, and requires no anesthesia.
The washed, concentrated sperm is introduced into the uterus via a thin catheter, enhancing the chances of conception.

2.2 IUI in stimulated cycle:

Cycle monitoring and treatment process:

Medical stimulation begins on day 2 of the menstrual cycle.
The goal of the treatment is to grow 2–4 high-quality follicles with more intensive monitoring than in a natural cycle.
Follicular growth is monitored via transvaginal ultrasounds throughout the cycle.
When the follicles reach the desired size, an ovulation-inducing injection is administered to time ovulation.
Insemination is performed about 36 hours after triggering ovulation.

Important information:

In a stimulated cycle, the chance of multiple follicles maturing increases, so the safety of continuing treatment is assessed individually in each case.
The procedure involves delivering the prepared sperm sample directly into the uterine cavity via a thin, flexible catheter.
Insemination takes approximately 5–10 minutes, is entirely painless, and requires no anesthesia.

3 IVF (In Vitro Fertilization)

IVF is one of the most effective methods for treating infertility. During treatment, the eggs are fertilized outside the body in a laboratory using the partner's sperm. The resulting embryos (typically on day 5–6 of development, at the blastocyst stage) are either transferred into the uterus or frozen for later transfer. IVF is especially recommended when other reproductive methods have been unsuccessful.

Stages of IVF:

Hormonal Stimulation (10–12 days)

Goal: To mature multiple eggs simultaneously in the ovaries.

Stimulation begins on cycle day 2 following a medication protocol prescribed by the doctor (injections and/or tablets).
Several monitoring visits are conducted (usually around cycle days 8, 10, and 12) using ultrasound and lab tests to track ovarian response and hormone levels.
When the follicles reach the desired size, an ovulation-triggering injection (e.g., Ovitrelle) is administered to precisely time ovulation.

Egg Retrieval (Puncture)

Timing: 36 hours after the ovulation-triggering injection.

The procedure is performed under anesthesia and guided by transvaginal ultrasound.
The contents of the follicles are aspirated using a thin needle, and the eggs are immediately isolated and assessed in the laboratory.
The procedure is short (approx. 10–15 minutes), and after a few hours of observation, the patient can go home.

Fertilization (Classic IVF or ICSI)

IVF (Classic): Eggs are incubated with sperm, allowing natural fertilization to occur.
ICSI (Intracytoplasmic Sperm Injection): A single sperm is injected directly into the egg using micromanipulation techniques.

Embryo Culture

Fertilized eggs are cultured in laboratory conditions for 5–6 days.
Development and cell division are continuously monitored; viable blastocysts are either frozen or prepared for transfer.
If needed, genetic testing (PGT-A) may be performed on day 5–6, after which the embryos are frozen. This is particularly recommended after repeated implantation failure, miscarriages, or in certain age-related cases.

Embryo Transfer

Fresh cycle: Transfer occurs on day 5 after egg retrieval.
Frozen embryo transfer (FET): Performed in a later cycle if the hormonal environment is not ideal or if PGT-A testing was done.
The procedure is painless.
The selected embryo is transferred into the uterine cavity via a thin catheter. After a short rest, the patient can go home, bed rest is not required.

Luteal Support and Pregnancy Test

β-HCG pregnancy test after 14 days.
Hormone support usually continues until week 10 if pregnancy is confirmed.

Personalized Treatment Approach

Our comprehensive treatment process is tailored to each couple's unique situation, ensuring the highest chances of success through careful monitoring and expert medical care.